An improved synthesis of 2-oxa-7-azaspiro [3, 5] nonane and analogs as novel reagents in medicinal chemistry

R Xu, M Czarniecki, J de Man, J Pan, L Qiang, Y Root…

Index: Tetrahedron Letters, , vol. 52, # 26 p. 3266 - 3270

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Citation Number: 7

Abstract

... Tetrahedron Letters. ... Although these two moieties have roughly the same van der Waals volume, the oxetane ring could significantly improve the physical properties of ... 3,5]nonane 1b starting from the unstable and expensive oxetan-3-one 4 was described in the above Letter (Fig ...