Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives

F Bouchikhi, F Anizon, P Moreau

Index: Bouchikhi, Fadoua; Anizon, Fabrice; Moreau, Pascale European Journal of Medicinal Chemistry, 2008 , vol. 43, # 4 p. 755 - 762

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Citation Number: 33

Abstract

In the course of structure–activity relationship studies, diversely substituted 1-(β-d- acetylatedglucopyranosyl) isoindigo derivatives were prepared from indolines. New 7′- azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7- azaindolin-2-one derivative. Compounds containing a 7′-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the ...