Novel quinazolinone derivatives as 5-HT 7 receptor ligands
…, SH Hong, JH Lee, WK Park, DJ Baek, HY Koh…
Index: Na, Yong Ho; Hong, Sung Ho; Lee, Jung Hyang; Park, Woo-Kyu; Baek, Du-Jong; Koh, Hun Yeong; Cho, Yong Seo; Choo, Hyunah; Pae, Ae Nim Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2570 - 2578
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Citation Number: 50
Abstract
5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the involvement of the 5-HT7 receptor in other pathophysiological mechanisms such as thermoregulation, learning and memory, and sleep has been highlighted by various studies. As one of our efforts to discover a new type of 5-HT7 receptor antagonists, we here report on the synthesis and binding affinities to the 5-HT7 receptor of the quinazolinone library 1, ...
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