Total synthesis of leukotriene B4 [(+)-LTB4] and homo-LTB4 from D-mannitol

…, C Gravier-Pelletier, D Micas-Languin…

Index: Merrer, Yves Le; Gravier-Pelletier, Christine; Micas-Languin, Dominique; Mestre, Francoise; Dureault, Annie; Depezay, Jean-Claude Journal of Organic Chemistry, 1989 , vol. 54, # 10 p. 2409 - 2416

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Citation Number: 25

Abstract

In the last few years, there has been considerable interest in hydroxylated eicosatetraenoic acids derived from arachidonic acid by lipoxygenase metabolic pathways. Leukotriene B4 biosynthetized via the 5-lipoxygenase pathway1 is one of the most potent chemotactic agents produced by human polymorphonuclear leukocytes. Implicated as