Synthesis of a radioiodinated park nucleotide analog: A new tool for antibacterial screen development
CN Eid, MJ Nesler, M Zia??Ebrahimi…
Index: Eid, Clark N.; Nesler, Michael J.; Zia-Ebrahimi, Mohammad; Wu, Chuyn-Yeh Ernie; Yao, Raymond; Cox, Karen; Richardson, John Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 8 p. 705 - 716
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Abstract
Abstract The Park nucleotide is an important biological building block used in the construction of bacterial cell walls. Herein, we describe the synthesis of a radiolabeled Park nucleotide analog, p-iodophenoxyacyl-Ala-(d)-iso-Glu-Lys-(d)-Ala-(d)-Ala-OH-[123 I], using electrophilic destannylation. Anti-Park nucleotide antibody binding assays using a scintillation proximity assay (SPA) system showed good recognition of the radiolabeled ...
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