Journal of medicinal chemistry

Structure-activity study of 5-substituted 1-carbobenzoxy-2-iminohydantoins as potential anticonvulsant agents

Z Sun, CH Kwon, JND Wurpel

Index: Sun, Zhong-Yue; Kwon, Chul-Hoon; Wurpel, John N. D. Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2841 - 2845

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Citation Number: 17

Abstract

On the basis of our previous findings, a series of 5-substituted 2-iminohydantoins has been synthesized and tested for anticonvulsant activity to better understand the SAR of 2- iminohydantoins. Among the compounds tested,(SI-(+)-l-carbobenzoxy-2-iminohydantoin analogs with ethyl (6)-, n-propyl (7a)-, isopropyl (8)-, allyl (9)-, and sec-butyl (Wsubstituted groups at the C5 of the iminohydantoin ring provided the best activities against the MES ...