Sulfonyl-polyol N, N-dichloroamines with rapid, broad-spectrum antimicrobial activity

…, DJR O'Mahony, L Friedman, L D'Lima, A Jekle…

Index: Shiau, Timothy P.; Low, Eddy; Kim, Bum; Turtle, Eric D.; Francavilla, Charles; O'Mahony, Donogh J.R.; Friedman, Lisa; D'Lima, Louisa; Jekle, Andreas; Debabov, Dmitri; Zuck, Meghan; Alvarez, Nichole J.; Anderson, Mark; Najafi, Ramin; Jain, Rakesh K. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5650 - 5653

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Abstract

Abstract The discovery and development of antimicrobial agents that do not give rise to resistance remains an ongoing challenge. Our efforts in this regard continue to reveal new potential therapeutic agents with differing physicochemical properties while retaining the effective N, N-dichloroamine pharmacophore as the key antimicrobial warhead. In this Letter, we disclose agents containing polyol units as a water solubilizing group. These ...