Tetrahedron Letters

A facile preparation of tetralins from arene-1, 4-diones using titanium (IV) chloride and triethylsilane

G Li, Q Xiao, C Li, X Wang, D Yin

Index: Li, Gang; Xiao, Qiong; Li, Chun; Wang, Xiaojian; Yin, Dali Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6827 - 6830

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Citation Number: 7

Abstract

A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1, 4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium (IV) chloride catalyzed cyclization.

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