Journal of the American Chemical Society

Synthesis of α-Amino-γ-halogenobutyric Acids. A New Synthesis of DL-Homoserine

M Frankel, Y Knobler

Index: Frankel; Knobler Journal of the American Chemical Society, 1958 , vol. 80, p. 3147

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Citation Number: 12

Abstract

In the course of our investigations on trifunctional a-aminobutyric acids we have worked out new syntheses of a-amino-7-halogenobutyric acids and of DL-homoserine2 (a-amino-y- hydroxybutyric acid). The convenient synthesis of the latter is based on the use of a-amino-y- iodobutyric acid hydroiodide (11). This substance is prepared in 70y0 yield by amination of a- bromo-y-butyrolactone3 (I) and subsequent opening of the intermediate a-amino-y- ...