Morpholinoalkyl ester prodrugs of diclofenac: synthesis, in vitro and in vivo evaluation

VK Tammara, MM Narurkar, AM Crider…

Index: Journal of Pharmaceutical Sciences, , vol. 83, # 5 p. 644 - 648

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Citation Number: 63

Abstract

... yielded 1.4 g of white crystalline 2; IR (KBr): 1736 (C=O, ester) cm-l; NMR (CDC13): 6 2.44 (m, 4H, J = 5.7 Hz, N(CHzCH2)2), 2.63 (t, 2H, J = 5.7 Hz, CH2-N), 3.62 (m, 4H, O(CH2CH2)2), 3.82 (s, 2H, CH2-Ar), 4.29 (t, 2H, J = 5.7 Hz ... 646 /Journal of Pharmaceutical Sciences Vol. ...

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