Polycyclic N??heterocyclic compounds, part 67: Reaction of 6, 7??substituted N??(quinazolin??4??yl) amidine derivatives with hydroxylamine hydrochloride: Formation of in …

K Okuda, H Muroyama, T Hirota

Index: Okuda, Kensuke; Muroyama, Hideki; Hirota, Takashi Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 6 p. 1407 - 1413

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Citation Number: 5

Abstract

Abstract Reactions of N-(quinazolin-4-yl) amidines and their amide oximes with hydroxylamine hydrochloride gave cyclization products that were formed by an initial ring cleavage of the pyrimidine component followed by a ring closure formation of 1, 2, 4- oxadiazole to give N-[2-([1, 2, 4] oxadiazol-5-yl) phenyl] formamide oximes. All isolated products were evaluated for in vitro inhibitory activity on the formation of pentosidine, ...