Design and synthesis of 3, 4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: new lead-agents with analgesic and …

HJC Bezerra-Netto, DI Lacerda, ALP Miranda…

Index: Bezerra-Netto, Heleno J.C.; Lacerda, Daniel I.; Miranda, Ana Luisa P.; Alves, Helio M.; Barreiro, Eliezer J.; Fraga, Carlos A.M. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7924 - 7935

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Citation Number: 72

Abstract

In this work, we reported the synthesis and evaluation of the analgesic, anti-inflammatory, and antipyretic properties of new 2-(6-nitro-benzo [1, 3] dioxol-5-yloxy)-acetylhydrazone derivatives (3), designed exploring molecular hybridization and isosteric replacement approaches between nimesulide (1) and carbanalogue NAH series (2) developed at LASSBio. Target compounds were synthesized in very good yields exploiting abundant ...