Nucleosides. Part LXIII. Acetals as new 2′??O??protecting functions for the synthesis of oligoribonucleotides: Synthesis of uridine building blocks and evaluation of their …
…, HP Fitznar, R Schnell, W Pfleiderer
Index: Matysiak, Stefan; Fitznar, Hans-Peter; Schnell, Ralf; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1998 , vol. 81, # 8 p. 1545 - 1566
Full Text: HTML
Citation Number: 1
Abstract
Abstract A broad variety of new acyclic vinyl ethers (see 6–41) have been synthesized via the vinyl-interchange reaction of ethyl vinyl ether at room temperature using mercury (II) trifluoroacetate as a highly efficient catalyst. The appropriate vinyl ethers were reacted under acidic conditions with 3′, 5′-O-silyl-protected uridine 42 to the corresponding 2′-O-(1- alkoxyethyl) derivatives 43–83 which gave, on desilylation of F− ions, in high yields the ...
Related Articles:
[Florent, Jean-Claude; Dong, Xia; Gaudel, Gilbert; Mitaku, Sofia; Monneret, Claude; Gesson, Jean-Pierre; Jacquesy, Jean-Claude; Mondon, Martine; Renoux, Brigitte; Andrianomenjanahary, Solo; Michel, Sylvie; Koch, Michel; Tillequin, Francois; Gerken, Manfred; Czech, Joerg; Straub, Rainer; Bosslet, Klaus Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3572 - 3581]
[Krohn, Karsten; Franke, Claudia; Jones, Peter G.; Aust, Hans-Juergen; Draeger, Sigfried; Schulz, Barbara Liebigs Annalen der Chemie, 1992 , # 8 p. 789 - 798]