Convenient and stereospecific homologation ofN-fluorenylmethoxycarbonyl-α-amino acids totheir β-homologues

…, A Liguori, A Procopio, G Sindona

Index: Leggio, Antonella; Liguori, Angelo; Procopio, Antonio; Sindona, Giovanni Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 13 p. 1969 - 1971

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Citation Number: 47

Abstract

A very simple approach to the enantioselective homologation of α-amino acids is presented which is based on the formation of N-Fmoc-aminoacyldiazomethanes with nearly quantitative yields and on the complete retention of both chiral configuration and N-terminal protecting group in the overall transformation.

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