Oxidant Effect of H2O2 for the Syntheses of Quinoline Derivatives via One-Pot Reaction of Aniline and Aldehyde

Q Guo, W Wang, W Teng, L Chen, Y Wang…

Index: Guo, Qiaoxia; Wang, Wennian; Teng, Weiling; Chen, Liwei; Wang, Yanqing; Shen, Baojian Synthetic Communications, 2012 , vol. 42, # 17 p. 2574 - 2584

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Citation Number: 7

Abstract

A convenient one-pot method for the synthesis of substituted quinolines via the reaction of aniline and aldehyde in the presence of a Lewis acid (AlCl 3 ) and an oxidant (H 2 O 2 ) has been developed. Hydrogen peroxide was found to promote the reaction by its function as a hydrogen hunter, hindering the formation of by-product N-alkylaniline. The effect of the oxidant on the yield and selectivity was studied. When the molar ratio of aniline, n-butyraldehyde, and H 2 O 2 ...

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