IRAK-4 inhibitors. Part III: a series of imidazo [1, 2-a] pyridines

…, L Gowers, AP Higueruelo, LA James, K Jenkins…

Index: Buckley, George M.; Fosbeary, Richard; Fraser, Joanne L.; Gowers, Lewis; Higueruelo, Alicia P.; James, Lynwen A.; Jenkins, Kerry; Mack, Stephen R.; Morgan, Trevor; Parry, David M.; Pitt, William R.; Rausch, Oliver; Richard, Marianna D.; Sabin, Verity Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3656 - 3660

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Citation Number: 55

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Dedicated to the memory of our friend and colleague David Rainey. ... Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines ...