Organic letters

Enantiopure 1, 5-diols from dynamic kinetic asymmetric transformation. Useful synthetic intermediates for the preparation of chiral heterocycles

K Leijondahl, L Borén, R Braun, JE Bäckvall

Index: Leijondahl, Karin; Boren, Linnea; Braun, Roland; Baeckvall, Jan-E. Organic Letters, 2008 , vol. 10, # 10 p. 2027 - 2030

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Citation Number: 48

Abstract

Dynamic kinetic asymmetric transformation (DYKAT) of a series of 1, 5-diols has been performed in the presence of Candida antarctica lipase B (CALB), Pseudomonas cepacia lipase II (PS-C II), and ruthenium catalyst 4. The resulting optically pure 1, 5-diacetates are useful synthetic intermediates, which was demonstrated by the syntheses of both an enantiopure 2, 6-disubstituted piperidine and an enantiopure 3, 5-disubstituted ...

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