Fluorinated sugar analogs of potential anti-HIV-1 nucleosides

…, LC Chen, L Wang, MH Kim, JA Warshaw…

Index: Huang; Chen; Wang; Kim; Warshaw; Armstrong; Zhu; Chou; Watanabe; Matulic-Adamic; Su; Fox; Polsky; Baron; Gold; Hardy; Zuckerman Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1640 - 1646

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Citation Number: 53

Abstract

In order to obtain agenta with therapeutic indices superior to those of AZT, FLT, or D4T, several analogues of anti-HIV-1 nucleosides were synthesized. These include 2', 3'-dideoxy- 2', 3'-difluoro-5-methyluridine (13), ita arabino analogue 19, arabino-5-methylcytosine analogue 21, 3'-deoxy-2', 3'-didehydro-2'-fluorothymidine (25), Y-azido-2', 3'-dideoxy-2'- fluoro-5-methyluridine (29), 2'-azido-3'-fluoro-2', 3'-dideoxy-5-methyluridine (31), and 2', 3' ...