Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives

T Okaecwe, AJ Swanepoel, A Petzer, JJ Bergh…

Index: Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anel; Bergh, Jacobus J.; Petzer, Jacobus P. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4336 - 4347

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Citation Number: 9

Abstract

A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and-B. In an attempt to discover additional caffeine derivatives with potent MAO inhibitory activities, and to contribute to the known structure–activity relationships of MAO inhibition by caffeine derived compounds, the present study investigates the MAO inhibitory potencies of series of 8- ...