Concise stereoselective synthesis of (2 S, 4 R)-4-hydroxyproline from (S)-O-benzylglycidol a novel cyclization

S Takano, Y Iwabuchi, K Ogasawara

Index: Takano, Seiichi; Iwabuchi, Yoshiharu; Ogasawara, Kunio Journal of the Chemical Society, Chemical Communications, 1988 , # 23 p. 1527 - 1528

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Citation Number: 17

Abstract

Concise Stereoselective Synthesis of (2S,4R)-4-Hydroxyproline from (S)-0-Benzylglycidol by a Novel Cyclization ... Seiichi Takano," Yoshiharu Iwabuchi, and Kunio Ogasawara Pharmaceutical Institute, Tohoku University, Aoba yama, Sendai 980, Japan ... An efficient stereoselective route to (2S,4R)-4-hydroxyproIine from (S)-0-benzylglycidol has been established via a novel iodine-mediated cyclization of the N-benzoyl-y,G-unsaturated amide.

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