A synthesis of the HIV-protease inhibitor nelfinavir from D-tartaric acid

…, T Remarchuk, D Rieger, R Rodriguez, J Shanley…

Index: Albizati, Kim F.; Babu, Srinivasan; Birchler, Angela; Busse, Juliette K.; Fugett, Michelle; Grubbs, Alan; Haddach, Aubrey; Pagan, Miguel; Potts, Barbara; Remarchuk, Travis; Rieger, Dale; Rodriguez, Rick; Shanley, Jim; Szendroi, Robert; Tibbetts, Tony; Whitten, Kathleen; Borer, Bennett C. Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6481 - 6485

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Citation Number: 21

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... This letter describes a new synthesis of the HIV-protease inhibitor nelfinavir. The synthesis features a selective opening of a d-tartaric acid-derived cyclic sulfate with nitrogen nucleophiles. ... The epoxy-oxazoline 3 could be synthesized from aminoalcohol intermediate 4 which contains the oxazoline ...

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