Inhibition of purple acid phosphatase with α-alkoxynaphthylmethylphosphonic acids

RP McGeary, P Vella, JYW Mak, LW Guddat…

Index: McGeary, Ross P.; Vella, Peter; Mak, Jeffrey Y.W.; Guddat, Luke W.; Schenk, Gerhard Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 163 - 166

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Citation Number: 23

Abstract

Purple acid phosphatases (PAPs) are binuclear hydrolases that catalyse the hydrolysis of a range of phosphorylated substrates. Human PAP is a major histochemical marker for the diagnosis of osteoporosis. In patients suffering from this disorder, PAP activity contributes to increased bone resorption and, therefore, human PAP is a key target for the development of anti-osteoporotic drugs. This manuscript describes the design and synthesis of derivatives ...