Design of peptides with α, β-dehydro-residues: synthesis and crystal structure of a tripeptide N-benzyloxycarbonyl-ΔVal-ΔPhe-l-Ala-OCH 3

VK Goel, S Dey, TP Singh

Index: Goel, Vijay Kumar; Dey, Sharmistha; Singh, Tej P. Journal of Molecular Structure, 2005 , vol. 738, # 1-3 p. 189 - 192

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Abstract

In order to develop the design rules for producing specific conformations of peptides with α, β-dehydro-residues a peptide Cbz-ΔVal-ΔPhe-Ala-OCH3 was synthesized in solution phase. The crystal structure has been determined by X-ray diffraction method. The structure was refined to an R-value of 0.050. The peptide adopts a type I β-turn conformation with backbone torsion angles of two corner residues, ϕ1=− 53.9 (6)°, ψ1=− 33.0 (6)°, ϕ2=− ...