Improved Synthesis of 1-Aryl-2, 2-Dichloro-1-Alkanones

N De Kimpe, LD Buyck, R Verhé…

Index: De Kimpe,N. et al. Synthetic Communications, 1979 , vol. 9, p. 575 - 582

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Abstract

Abstract Recently1 we described a convenient synthesis of 1-aryl-2, 2-dichloro-1-alkanones 1 by a reaction sequence involving conversion of the parent alkylarylketones into the corresponding N-cyclohexylketimines, followed by chlorination with N-chlorosuccinimide in carbon tetrachloride to afford N-cyclo-hexyl α, α-dichloroketimines, the latter compounds being hydrolyzed in acidic medium to yield the title compounds 1. The relative ...

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