Toxicology

Nephrotoxic and hepatotoxic potential of imidazolidinedione-, oxazolidinedione-and thiazolidinedione-containing analogues of N-(3, 5-dichlorophenyl) succinimide ( …

EL Kennedy, R Tchao, PJ Harvison

Index: Kennedy, Erica L.; Tchao, Ruy; Harvison, Peter J. Toxicology, 2003 , vol. 186, # 1-2 p. 79 - 91

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Citation Number: 15

Abstract

Nephrotoxicity of the agricultural fungicide N-(3, 5-dichlorophenyl) succinimide (NDPS) in rats is believed to involve metabolism on the succinimide ring. To further investigate this hypothesis, we synthesized and tested the following NDPS analogues, which contain other cyclic imide rings and may therefore be metabolized differently than NDPS: 3-(3, 5- dichlorophenyl)-2, 4-oxazolidinedione (DCPO), 3-(3, 5-dichlorophenyl)-2, 4- ...