An Efficient Synthesis of a Key Intermediate of DU-6859a via Asymmetric Microbial Reduction.

…, A Imura, A Miyadera, K KANAI, Y YUKIMOTO

Index: Satoh, Koji; Imura, Akihiro; Miyadera, Akihiko; Kanai, Kazuaki; Yukimoto, Yusuke Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 587 - 590

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Citation Number: 19

Abstract

An efficient synthesis method for the C-7 substituent of DU-6859a (1), which is a new- generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5-benzyl-4, 7-dioxo-5-azaspiro [2.4] heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), ...