Synthesis and Photophysical Properties of a Deazaflavin??Bridged Porphyrinatoiron (III) That Mimics the Interaction of a Deazaflavin Inhibitor with the Heme??Thiolate …

…, M Gaplovsky, J Wirz, WD Woggon

Index: Mueller, Michael A.; Gaplovsky, Martin; Wirz, Jakob; Woggon, Wolf-D. Helvetica Chimica Acta, 2006 , vol. 89, # 12 p. 2987 - 3001

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Citation Number: 7

Abstract

Abstract Cytochrome P450 3A4 metabolizes a majority of administered therapeutic agents in the human liver. We recently reported the synthesis of a new inhibitor, 1, whose binding to and displacement from the active site of CYP 3A4 can be conveniently followed by the associated changes in fluorescence intensity. Here we report the synthesis of a bichromophoric compound, 6, in which deazaflavin was strapped over the distal side of a ...