Isoindolinone enantiomers having affinity for the dopamine D 4 receptor

…, SZ Whetzel, AE Corbin, TA Pugsley, TG Heffner…

Index: Belliotti, Thomas R.; Brink, Wouter A.; Kesten, Suzanne R.; Rubin, John R.; Wustrow, David J.; Zoski, Kim T.; Whetzel, Steven Z.; Corbin, Ann E.; Pugsley, Thomas A.; Heffner, Thomas G.; Wise, Lawrence D. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 12 p. 1499 - 1502

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Citation Number: 112

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... PD 108635 (1) was identified as a potent dopamine D 4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D 4 affinity. ... PD 108635 (1) was identified as a potent ...