Halogenated analogs of 1′-acetoxychavicol acetate, Rev-export inhibitor from Alpinia galanga, designed from mechanism of action

S Tamura, A Shiomi, T Kimura, N Murakami

Index: Tamura, Satoru; Shiomi, Atsushi; Kimura, Tominori; Murakami, Nobutoshi Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2082 - 2085

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Citation Number: 10

Abstract

In the course of search for the robust analogs of 1′-acetoxychavicol acetate (ACA, 1), the Rev-export inhibitor from the medicinal plant Alpinia galanga, we clarified formation of the quinone methide intermediate ii to be essential for exerting the inhibitory activity of 1. Based on this mechanism of action, the rational design from the MO calculation of the conclusive activation energy to ii resulted in the four halogenated analogs with more potent activity ...