Tetrahedron Letters

Studies of multicomponent Kinugasa reactions in aqueous media

CS McKay, DC Kennedy, JP Pezacki

Index: McKay, Craig S.; Kennedy, David C.; Pezacki, John Paul Tetrahedron Letters, 2009 , vol. 50, # 17 p. 1893 - 1896

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Citation Number: 30

Abstract

Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a 'single pot'for a series of in situ generated C, N-diphenylnitrones with Cu (I) phenylacetylide providing β-lactams in yields of 45–85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.

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