… key reagents for the simple preparation of heteroarylcarboxamides with potential biological activity. Part 1 reaction of methanetricarboxylates with indoline and 1, 2, 3, …

A Kutyrev, T Kappe

Index: Kutyrev, Alexander; Kappe, Thomas Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 969 - 972

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Citation Number: 23

Abstract

Abstract The reaction of methanetricarboxylates 2a, b with indoline as well as 1, 2, 3, 4- tetrahydroquinoline yields tricyclic 4-hydroxy-2 (1H)-quinolones with an ester group in position 3 (3, 8a, b). These heterocyclic esters condense with primary aliphatic, aromatic, and heteroaromatic amines to give the corresponding amides 5a-e and 10a-t.