Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

…, G Krishnamurthy, A Aulabaugh, GS Friedrichs…

Index: Gopalsamy, Ariamala; Kincaid, Scott L.; Ellingboe, John W.; Groeling, Thomas M.; Antrilli, Thomas M.; Krishnamurthy, Girija; Aulabaugh, Ann; Friedrichs, Gregory S.; Crandall, David L. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3477 - 3480

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Citation Number: 24

Abstract

A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure–activity relationship to improve potency are described.