Synthesis of 3-halopyrroles

N De Kimpe, KA Tehrani, C Stevens, P De Cooman

Index: De Kimpe, Norbert; Tehrani, Kourosch Abbaspour; Stevens, Christian; De Cooman, Paul Tetrahedron, 1997 , vol. 53, # 10 p. 3693 - 3706

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Citation Number: 51

Abstract

3-Chloro-and 3-bromo-2-arylpyrroles, which are potential physiologically active compounds in agrochemistry and pharmaceutical sciences, were efficiently prepared from the corresponding 2-aryl-1-pyrrolines by α, α-dihalogenation with N-halosuccinimides and subsequent base-induced monodehydrohalogenation using sodium methoxide in methanol.