A convenient reduction of amino acids and their derivatives

MJ McKennon, AI Meyers, K Drauz…

Index: McKennon, Marc J.; Meyers, A. I.; Drauz, Karlheinz; Schwarm, Michael Journal of Organic Chemistry, 1993 , vol. 58, # 13 p. 3568 - 3571

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Citation Number: 558

Abstract

The formation of chiral amino alcohols by reduction of amino acids has been the subject of considerable effort due to their importance in asymmetric synthesis? peptide and pharmaceutical chemistry: resolution of racemic mixtures: synthesis of insecticidal compounds: and others. From the earliest reports by Karrer in 1921, amino alcohols were prepared by reduction of the corresponding amino acid esters with sodium in ethanol. & ...

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