Synthesis and anti-HIV activity of new C 2 symmetric derivatives designed as HIV-1 protease inhibitors

…, LJO Figueiredo, RM Brindeiro, A Tanuri, AR Calazans…

Index: Pecanha, Emerson P.; Figueiredo, Luciana J.O.; Brindeiro, Rodrigo M.; Tanuri, Amilcar; Calazans, Alexandre R.; Antunes Farmaco, 2003 , vol. 58, # 2 p. 149 - 157

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Citation Number: 13

Abstract

The synthesis of several new anti-HIV-1 compounds is described. The new compounds contain a C2 symmetry axis and a dihidroxyethylene moiety based on the d-tartaric acid back bone. The synthesis of these compounds was achieved in 36–69% overall yields from d-tartaric acid. The protocol included: acetylation of hydroxyl groups, followed by diamide formation and deacetylation or reduction with LiAlH4. The anti-HIV 1 activities of these ...