Synthesis

First synthesis of N-acylated photoactivatable analogues of glutathione bearing an aryl azide moiety

D Bernardi, LA Ba, G Kirsch

Index: Bernardi, Dan; Ba, Lalla Aicha; Kirsch, Gilbert Synthesis, 2007 , # 1 p. 140 - 144

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Citation Number: 7

Abstract

N-Acylated photoactivatable analogues of glutathione bearing an aryl azide moiety were synthesized for the first time starting from S-tritylglutathione. ... Figure 1 Structures of new photoactivatable analogues of glutathione. ... Scheme 1 Reagents and conditions: (i) N-hydroxysuccinimidyl 4-benzoylbenzoate, Et 3 N, H 2 O, MeCN, rt, 36 h (ii) dithiothreitol, H 2 O, rt, argon, overnight. ... Scheme 2 Reagents and conditions: (i) N-hydroxysuccinimidyl 4-benzoylbenzoate, Et ...