De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

RM Brady, A Vom, MJ Roy, N Toovey…

Index: Journal of Medicinal Chemistry, , vol. 57, # 4 p. 1323 - 1343

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Citation Number: 12

Abstract

... Journal of Medicinal ... The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. ‡ Department of Medical Biology, The ... Abstract Image. The prosurvival BCL-2 proteins are attractive yet challenging targets for medicinal chemists. ...