Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents

…, X Wang, W Zhang, X Wang, L Chen, Z Huang…

Index: Ling, Yong; Wang, Zhiqiang; Zhu, Hongyan; Wang, Xuemin; Zhang, Wei; Wang, Xinyang; Chen, Li; Huang, Zhangjian; Zhang, Yihua Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 374 - 380

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Citation Number: 11

Abstract

Abstract Fourteen hybrids of farnesylthiosalicylic acid (FTS) with various diamines were synthesized and biologically evaluated. It was found that FTS-monoamide molecules (10a– g) displayed strong anti-proliferative activity against seven human cancer cell lines, superior to FTS and FTS-bisamide compounds (11a–g). The mono-amide 10f was the most active, with IC 50 s of 3.78–7.63 μM against all tested cancer cells, even more potent than ...

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