2??Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms

…, AS Breitbach, HE Blackwell

Index: Frei, Reto; Breitbach, Anthony S.; Blackwell, Helen E. Angewandte Chemie - International Edition, 2012 , vol. 51, # 21 p. 5226 - 5229

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Citation Number: 57

Abstract

Bacteria can grow into surface-associated communities termed biofilms that are pervasive virtually everywhere on earth.[1] This mode of growth poses a significant obstacle to the successful treatment of infectious disease, with an estimated 80% of human infections in the biofilm state.[2] Biofilms are particularly problematic to clear because of their encasement in a protective and impermeable extracellular matrix,[3] which renders biofilm-associated ...