Evidence of the preferential involvement of. mu.-receptors in analgesia using enkephalins highly selective for peripheral. mu. or. delta. receptors

G Gacel, MC Fournie-Zaluski, E Fellion…

Index: Gacel, Gilles; Fournie-Zaluski, Marie-Claude; Fellion, Etienne; Roques, Bernard P. Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1119 - 1124

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Citation Number: 73

Abstract

In order to study the preferential involvement of p or 6 receptors in the analgesic effects of enkephalins, several peptides which selectively interact with these two kinds of receptors in peripheral organs were synthesized. The inhibitory potency on the electrically stimulated mouse vas deferens (6 receptors) of the short peptide WD-