Hydroxylation of DHEA and its analogues by Absidia coerulea AM93. Can an inducible microbial hydroxylase catalyze 7α-and 7β-hydroxylation of 5-ene and 5α- …

N Milecka-Tronina, T Kołek, A Świzdor…

Index: Milecka-Tronina, Natalia; Kolek, Teresa; Swizdor, Alina; Panek, Anna Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 883 - 891

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Citation Number: 7

Abstract

Abstract In this paper we focus on the course of 7-hydroxylation of DHEA, androstenediol, epiandrosterone, and 5α-androstan-3, 17-dione by Absidia coerulea AM93. Apart from that, we present a tentative analysis of the hydroxylation of steroids in A. coerulea AM93. DHEA and androstenediol were transformed to the mixture of allyl 7-hydroxy derivatives, while EpiA and 5α-androstan-3, 17-dione were converted mainly to 7α-and 7β-alcohols ...

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