'Goldilocks effect'of water in Lewis-Brønsted Acid and Base catalysis

BJ Barron, WT Wong, P Chiu, KKM Hii

Index: Taylor, Laura L.; Goldberg, Frederick W.; Hii, King Kuok Mimi Organic and Biomolecular Chemistry, 2012 , vol. 10, # 22 p. 4424 - 4432

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Abstract

Different catalytic protocols were evaluated in the enantioselective Pd-catalyzed aza- Michael reaction involving mono-protected phenylenediamine (PDA) derivatives. The use of these nucleophilic amines leads to the poisoning of the (monomeric) Lewis acidic catalyst,