Room Temperature, Metal??Free Arylation of Aliphatic Alcohols

R Ghosh, E Lindstedt, N Jalalian, B Olofsson

Index: Ghosh, Raju; Lindstedt, Erik; Jalalian, Nazli; Olofsson, Berit ChemistryOpen, 2014 , vol. 3, # 2 p. 54 - 57

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Citation Number: 18

Abstract

Abstract Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron- withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has been applied to the formal ...