Palladium (0)??Catalyzed Carbon Hydrogen Bond Functionalization for the Synthesis of Indoloquinazolinones

…, M Okuno, H Nishiguchi, Y Takemoto

Index: Tsukano, Chihiro; Okuno, Masataka; Nishiguchi, Hiromi; Takemoto, Yoshiji Advanced Synthesis and Catalysis, 2014 , vol. 356, # 7 p. 1533 - 1538

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Citation Number: 4

Abstract

Abstract: The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium (0)- catalyzed cyclization of chloroquinazolinone via CÀH functionalization was developed for ...