Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity

…, J Arnt, V Boeck, AV Christensen, J Hyttel…

Index: Boegesoe, Klaus P.; Arnt, Joern; Boeck, Vita; Christensen, A. Vibeke; Hyttel, John; Jensen, Klaus Gundertofte Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2247 - 2256

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Citation Number: 27

Abstract

A series of trans-1-piperazino-3-phenylindans were synthesized with the goal of replacing their established neuroleptic profile with that of peripheral 5-hydroxytryptamine (5-HTz) antagonism. Compounds with an unsubstituted or fluoro-substituted 6-position in the indan ring, and which had a five-or six-membered heterocyclic ring attached by an ethylene chain to the piperazine ring, satisfied this objective. Some of the compounds had potent ...