The selective enzymatic synthesis of lipophilic esters of swainsonine

GG Perrone, KD Barrow, IJ McFarlane

Index: Perrone, Gabriel G.; Barrow, Kevin D.; McFarlane, Ian J. Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 5 p. 831 - 835

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Citation Number: 16

Abstract

The potent and specific inhibitor of Golgi α-mannosidase II, swainsonine (SW) has been isolated in high yield from Swainsona procumbens and derivatised by regiospecific enzymatic reactions. In this study the regioselectivity of three commercially available enzymes, subtilisin Carlsberg, porcine pancreatic lipase (PPL) and Candida cylindracea lipase was determined for the acylation of swainsonine in predominantly anhydrous ...