Hydroxyl may not be indispensable for raltegravir: design, synthesis and SAR studies of raltegravir derivatives as HIV-1 inhibitors

Z Wang, M Wang, X Yao, Y Li, W Qiao, Y Geng…

Index: European Journal of Medicinal Chemistry, , vol. 50, p. 361 - 369

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Citation Number: 20

Abstract

... European Journal of Medicinal Chemistry. ... a: Cbz-Cl, K 2 CO 3 ; b: ClCO 2 C 2 H 5 , NH 3 ·H 2 O; c: (CF 3 CO) 2 O, NEt 3 ; d: NH 2 OH HCl, KOH; e: DMADC, CHCl 3 ; f: xylene, reflux; g: pyridine, (PhCO) 2 O; h: Me 2 SO 4 , LiH, 1,4-Dioxane; i: 10% Pd/C, H 2 , HCl; j: 17, NEt 3 ; k ...