Tetrahedron Letters

A convenient synthesis of linear pyridinoimidazo [1, 2-a] pyridine and pyrroloimidazo [1, 2-a] pyridine cores

M Andaloussi, E Moreau, O Chavignon, JC Teulade

Index: Andaloussi, Mounir; Moreau, Emmanuel; Chavignon, Olivier; Teulade, Jean C. Tetrahedron Letters, 2007 , vol. 48, # 47 p. 8392 - 8395

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Citation Number: 9

Abstract

Two new imidazo [1, 2-a] pyridine derivatives, pyridinoimidazo [1, 2-a] pyridine (10) and pyrroloimidazo [1, 2-a] pyridine (16), were synthesised from 2-amino-4-methyl-5- nitropyridine (1) by linear cyclisation, making use of dimethylformamide dimethylacetal (DMFDMA) as an agent of vinylamine functionalisation. This report describes first the formation of pyridine and pyrroloimidazopyridine from (1), and then the formation of ...