Synthesis and potent antibacterial activity against MRSA of some novel 1, 2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidines

H Göker, S Özden, S Yıldız, DW Boykin

Index: Goeker, Hakan; Oezden, Seckin; Yildiz, Sulhiye; Boykin, David W. European Journal of Medicinal Chemistry, 2005 , vol. 40, # 10 p. 1062 - 1069

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Citation Number: 124

Abstract

A series of 28 novel 1, 2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) by the tube dilution method. The results showed that compounds 45–46 and 55–57, having 3, 4-dichloro substituted phenyl at the position C-2, of N-bulky alkyl substituted ...