Enantioselective syntheses of no-carrier-added (nca)(s)-4-chloro-2-[18 f] fluorophenylalanine and (s)-(α-methyl)-4-chloro-2-[18 f] fluorophenylalanine

MJ Al-Darwich, A Plenevaux, C Lemaire…

Index: Al-Darwich; Plenevaux; Lemaire; Fiore; Christiaens; Comar; Luxen Journal of Fluorine Chemistry, 1996 , vol. 80, # 2 p. 117 - 124

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Citation Number: 5

Abstract

(S)-4-Chloro-2-fluorophenylalanine and (S)-(α-methy)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (nca) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F] fluorobenzyl iodide and the lithium enolate of (2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3- methyl-1, 3-imidazolidine-4-one for (S)-4-chloro-2-[18F] fluorophenylalanine and (2S, 5S)- ...